The article presents the pathomorphological changes in the femoral head tissue of 43 patients infected with Covid-19 who underwent hip replacement surgery. It was found that the more time passes after the illness in patients with Covid-19, the more the pathomorphological changes in the femoral head tissue increase. Hydropic dystrophy of chondrocytes and an increase in the number of necrotic cells are clearly visible. It is noted that fibrous tissue has grown between them.

This study presents the formulation and comprehensive evaluation of an herbal skin cream designed to enhance wound healing activity. The cream was meticulously formulated using a blend of herbal extracts known for their wound healing properties. The evaluation encompassed various parameters, including physicochemical characteristics, stability, antimicrobial efficacy, and in vitro wound healing potential. The cream exhibited desirable physicochemical properties and remained stable over the study period. Antimicrobial testing demonstrated its effectiveness against common wound pathogens. In vitro wound healing assays revealed the cream's ability to promote cell proliferation and migration, thus highlighting its potential as a therapeutic option for wound management. This research contributes to the development of herbal-based interventions for wound healing, bridging traditional knowledge with modern scientific evaluation.

Chronopharmacology presents a novel approach to drug delivery scheduling that acknowledges the inherent rhythmic variations in physiological processes, offering optimized therapeutic outcomes. This study explores the concept of chronopharmacology as a transformative paradigm for drug administration timing. By considering circadian rhythms, biological fluctuations, and organ-specific patterns, the study highlights the potential to enhance drug efficacy, minimize side effects, and improve patient compliance. A comprehensive review of existing literature elucidates the influence of circadian clocks on drug pharmacokinetics and pharmacodynamics, revealing opportunities for precision medicine. Moreover, the study discusses technological advancements and strategies to implement personalized chronopharmacological regimens. Through this exploration, the study advocates for the integration of chronopharmacology into clinical practice, ultimately paving the way for tailored drug delivery schedules that maximize therapeutic impact.