Chronopharmacology presents a novel approach to drug delivery scheduling that acknowledges the inherent rhythmic variations in physiological processes, offering optimized therapeutic outcomes. This study explores the concept of chronopharmacology as a transformative paradigm for drug administration timing. By considering circadian rhythms, biological fluctuations, and organ-specific patterns, the study highlights the potential to enhance drug efficacy, minimize side effects, and improve patient compliance. A comprehensive review of existing literature elucidates the influence of circadian clocks on drug pharmacokinetics and pharmacodynamics, revealing opportunities for precision medicine. Moreover, the study discusses technological advancements and strategies to implement personalized chronopharmacological regimens. Through this exploration, the study advocates for the integration of chronopharmacology into clinical practice, ultimately paving the way for tailored drug delivery schedules that maximize therapeutic impact.

drug delivery scheduling, circadian rhythms, biological fluctuations

Gupta, P.D. and Pushkala, K. (2012) Clocks within us LAMBERT Academic Publishing, GmbH & Co. KG, Saarbrücken, Germany.

Pushkala, K. and Gupta,P.D. (2011) Dark side of the night light (Monograph) LAMBERT Academic Publishing, GmbH & Co. KG, Saarbrücken, Germany.

Seán T. Anderson, Garret A. (2020) FitzGerald Sexual dimorphism in body clocks Science 369, ( 6508)1164-1165.

Gupta P D in Concepts in Chronopharmacology. ed N. (2009) Udupa and P D Gupta, Shyam Prakashan, Jaipur.

Gupta P D Hormone Harmony, Publication Division CSIR, New Delhi, 1996.

Kuila, A., N. V. Dhandapani, H. Bhowmik, A. Soni, and K. H. Kumar. Asian J Pharm Clin Res. 11, (8), 15-20, [ 2018]

Steven W. Lockley, Josephine Arendt Debra J. Skene, Dialogues Clin Neurosci. 9(3): 301–314. [2007]

S W Lockley, M A Dressman et al.. Lancet P1754-1764, [ 2015]

Christoph A Thaiss , Maayan Levy et al. Cell;167(6):1495-1510.e12. [2016]

Gupta A in Concepts in Chronopharmacology. ed N. (2009) Udupa and P D Gupta, Shyam Prakashan, Jiapur.