Petiveria alliacea, commonly known as guinea hen weed or anamu, is a medicinal plant renowned for its traditional uses in various folk medicine practices. This study aims to investigate the antimicrobial potential and mechanism of action of Petiveria alliacea stem extract against a panel of pathogenic microorganisms. Through a series of in vitro assays and molecular analyses, the antimicrobial activity of the extract was evaluated against bacterial and fungal strains. Results indicate significant inhibitory effects of Petiveria alliacea stem extract against a range of Gram-positive and Gram-negative bacteria, as well as fungal species. Furthermore, mechanistic investigations suggest that the extract exerts its antimicrobial action through multiple pathways, including disruption of cell membrane integrity, inhibition of enzyme activity, and modulation of microbial growth kinetics. These findings shed light on the antimicrobial properties of Petiveria alliacea stem extract and provide insights into its potential as a natural antimicrobial agent for therapeutic applications.

Petiveria alliacea, guinea hen weed, antimicrobial activity

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