Liver injury induced by paracetamol (acetaminophen) remains a significant concern, necessitating the exploration of effective hepatoprotective agents. This study investigates the potential hepatoprotective effects of Curcuma mangga extract in male mice subjected to paracetamol-induced hepatic injury. Following standardized protocols, male mice were pre-treated with Curcuma mangga extract before paracetamol administration. Hepatoprotective activity was assessed through biochemical markers, histopathological examination, and antioxidant enzyme assays. Results reveal a significant attenuation of paracetamol-induced hepatic injury in mice pre-treated with Curcuma mangga extract, as evidenced by reduced serum liver enzyme levels, ameliorated histopathological changes, and enhanced antioxidant enzyme activity. These findings underscore the hepatoprotective potential of Curcuma mangga extract and highlight its therapeutic relevance in mitigating drug-induced liver injury.

Hepatoprotective, Curcuma mangga extract, paracetamol-induced liver injury

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