Articles | Open Access | Vol. 2 No. 03 (2022): Volume02 Issue03 | DOI: https://doi.org/10.37547/medical-fmspj-02-03-07

FEATURES OF COGNITIVE DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND THE EFFECT OF CYSTATIN C ON IT DEPENDING ON THE STAGE OF THE DISEASE

Sevara Muratbekovna Khudayarova , PhD student, Department of Neurology Tashkent Medical Academy, Tashkent, Uzbekistan
Gulnara Kutbitdinovna Rakhmatullaeva , Doctor of Medical Sciences, Associate Professor, Department of Neurology Tashkent Medical Academy, Tashkent, Uzbekistan

Abstract

Chronic kidney disease (CKD) is a global problem of modern medicine. The neurological complications arising from this disease are an integral part of this condition because the kidneys and the brain have a similar anatomical structure of the vessels and a similar physiological structure of the processes occurring in them. Cognitive disorders (CD) that occur in CKD accompany almost every patient, regardless of the stage of the disease, and affect the psychological and social quality of life of patients. According to the literature, there are a number of substances called biomarkers, by determining which we can identify emerging neurological complications in the early stages of CKD. In our work, we used a new biomarker of renal function, cystatin C, which is characterized by free glomerular filtration and is not subject to tubular secretion. Its level in the blood serum of patients does not depend on the age, gender, muscle mass, ethnicity, diet, physical activity and bad habits of the patient.

Keywords

Chronic kidney disease (CKD), cognitive impairment (CD), cystatin C

References

Etgen T, Chonchol M, Ferstl H, Sander D. Chronic kidney disease and cognitive impairment: a systematic review and meta-analysis. Am J Nephrol 2012; 35(5): 474-82.

Hill NR, st. Fatoba, Oke JL et al. Global prevalence of chronic kidney disease: a systematic review and meta-analysis. PLOS One 2016; 11(7): e0158765.

Khrulev A.E., Studyanikova S.F., Langraf S.V. Cognitive disorders in patients on hemodialysis. Bulletin of Neurology 2019; 51(2):36-40. Russian [Khrulov A. E., Studyanikova S. F., Langraf S. V. et al. Cognitive impairment in patients on program hemodialysis. Neurological Bulletin 2019; 51(2):36-40]

Khrulev A.E., Tolbuzova D.D., Plokhenko E.A. Cognitive status and risk factors for cognitive impairment in dialysis patients. General resuscitation 2020; 16(4):21-31. Russian [Khrulev A. E., Tolbuzova D. D., Plokhenko E. A. et al. Cognitive status and risk factors for cognitive impairment in dialysis patients. General resuscitation 2020; 16(4):21-31).]

Mark P.B. // Cardiovascular risk management strategies in chronic kidney disease // Transplant Nephrological Dialysis 2017; 33(1):23-5.

Nathan E., Penersen S. E. Dialysis encephalopathy // Acta.Pediatr. Scand. - 1980. - No. 69. - S. 793-796.

Nikitina A.A., Khrulev A.E. Cerebral circulation disorders in the pre-dialysis period of chronic kidney disease and mechanisms of their development. Medical Almanac 2018; 56(5):28-32. Russian [Nikitina A. A., Khrulev A. E. Cerebrovascular devices in the pre-dialysis period of chronic kidney disease and mechanisms of their development.Medical Almanac 2018; 56(5):28-32)]

Raskin Neil H. Neurological aspects of renal failure // Neurology and General Medicine / Ed. M.J. Aminoff. - 3rd ed. -2001. - S. 231-246.

Rogova I.V., Fomin V.V., Damulin I.V. Vascular cognitive impairment in chronic kidney disease. Neurology, neuropsychiatry, psychosomatics 2015; 7(1):11-8. Russian [Rogova I. V., Fomin V. V., Damulin I. V. et al. Vascular cognitive impairment in chronic kidney disease. Neurology, neuropsychiatry, psychosomatics 2015; 7(1):11-8].

K/DOQI Clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification // Amer. J. Dis. ... cand. honey. Sciences - 2007. - No. 39 (2). - P. 5-266.

Chronic kidney disease: Clinical guidelines / Russian Association of Nephrologists, 2019. [Chronic kidney disease: clinical guidelines / Russian Association of Nephrologists, 2019. URL: http://nonr.ru/wp-content/downloads/2020/01/Clin_guidlines_CKD_24 11_final-3–3. pdf (March 12, 2020)]

Charre D.W., Chang S.I., Merden R.A. et al. Brief Cognitive Assessment Tool for Mild Cognitive Impairment (MCI) and Early Dementia. Alzheimer's Disorder Association 2010;(24): 64-71.

Murkamilov I. T., Sabirov I. S., Fomin V. V., Murkamilova Zh. A., Aitbaev K. A., Raimzhanov Z. R. Assessment of nephrocerebral risk in the use of cystatin C in patients with chronic kidney disease. Journal of Neurology and Psychology named after S.S. Korsakova. 2018;118(9):10-16. https://doi.org/10.17116/jnevro201811809110

Hashimoto N., Nishiyama S., Watanabe T., Vanezaki M, Yamaura G, Arimoto T, Takahashi H, Shishido T, Miyamoto T, Kubota I. Abstract 13956: Estimated glomerular filtration rate based on Cystatin C is an Acceptable Parameter for Stroke in Patients with Atrial Fibrillation. Circulation.2015;132:A13956

Etgen T, Chonchol M, Ferstl H, Sander D. Chronic kidney disease and cognitive impairment: a systematic review and meta-analysis. Am J Nephrol 2012; 35(5):474-82.

Estimated glomerular filtration rate based on Cystatin C is an acceptable Parameter for assessing stroke in Patients with Atrial Fibrillation. Circulation. 2015;132:A13956.

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Sevara Muratbekovna Khudayarova, & Gulnara Kutbitdinovna Rakhmatullaeva. (2022). FEATURES OF COGNITIVE DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND THE EFFECT OF CYSTATIN C ON IT DEPENDING ON THE STAGE OF THE DISEASE. Frontline Medical Sciences and Pharmaceutical Journal, 2(03), 67–77. https://doi.org/10.37547/medical-fmspj-02-03-07