Intertrochanteric femoral fractures with a thin lateral cortex pose a challenging scenario in orthopedic surgery. The stability and successful healing of these fractures largely depend on the choice of appropriate fixation modalities. This review aims to provide an overview of the various fixation techniques and modalities used in the management of thin lateral cortex - intertrochanteric femoral fractures. The literature search was conducted using electronic databases, including PubMed and Scopus, to identify relevant studies published between 2010 and 2023. The selected articles were analyzed to gather information on different fixation methods, including intramedullary nails, sliding hip screws, proximal femoral plates, and augmentation techniques. The efficacy, biomechanical properties, complications, and clinical outcomes associated with each fixation modality were evaluated. Furthermore, the influence of patient factors, fracture characteristics, and surgeon experience on the choice of fixation technique was also explored. This comprehensive review aims to provide orthopedic surgeons with evidence-based insights into the selection and application of fixation modalities for thin lateral cortex - intertrochanteric femoral fractures.

Thrombocytopenia, characterized by a decrease in platelet count, has been identified as a common complication in COVID-19 infection. This condition poses a significant risk for patients, as it can lead to severe bleeding and complications. While conventional medical treatments are available, the utilization of therapeutic natural medicines offers a promising alternative approach. This paper explores the potential of natural remedies in managing thrombocytopenia associated with COVID-19 infection. Through an extensive review of relevant literature, the efficacy and safety of various natural medicines such as herbal extracts, dietary supplements, and traditional remedies are examined. Additionally, the underlying mechanisms of action and potential synergistic effects are discussed. The findings highlight the potential of therapeutic natural medicines as a complementary and integrative approach to conventional treatments for COVID-19-related thrombocytopenia. Further research and clinical trials are warranted to validate their effectiveness and determine optimal treatment protocols.

Radicular pain, commonly caused by compression or irritation of spinal nerve roots, poses a significant challenge in terms of effective pain management. Current treatment options for radicular pain often have limited efficacy and are associated with various side effects. Therefore, there is a need for novel approaches in drug discovery to identify alternative therapies that target the underlying mechanisms of radicular pain. This review aims to explore emerging strategies and advancements in drug discovery for the treatment of radicular pain. It encompasses a comprehensive analysis of recent literature, focusing on novel targets, innovative drug delivery systems, and potential therapeutic interventions. The review also discusses the challenges and future directions in the field of drug discovery for radicular pain. By highlighting the latest research and advancements, this review aims to stimulate further investigation and development of novel therapeutic approaches to alleviate radicular pain and improve patient outcomes.

Urinary stone formation, known as urolithiasis, is a prevalent urological disorder affecting a significant portion of the population worldwide. The search for effective and safe therapeutic agents for the prevention and treatment of urolithiasis is ongoing. In this study, we employed in-silico screening techniques to evaluate the antiurolithiatic potential of lupeol, a natural compound derived from Bhadra (Aerva lanata Linn). Molecular docking simulations were performed to assess the binding affinity of lupeol with key target proteins involved in urolithiasis, including calcium oxalate crystal growth inhibitors, enzymes, and transporters. The results revealed that lupeol exhibited favorable binding interactions with these target proteins, suggesting its potential as an antiurolithiatic agent. Furthermore, molecular dynamics simulations were conducted to investigate the stability and dynamic behavior of the lupeol-protein complexes. The findings from this virtual exploration provide valuable insights into the molecular interactions and potential mechanisms underlying the antiurolithiatic activity of lupeol. Further experimental studies are warranted to validate these computational predictions and explore the therapeutic efficacy of lupeol in the prevention and management of urolithiasis.