The board of blood glucose level is the trademark in the treatment of diabetes. Much work has not been finished on the administration of diabetes utilizing the stem tuber concentrate of Colocasia esculenta. The creatures were given feed and water not indispensable. The pale skinned person rodents were directed for 28 days with the watery Colocasia esculenta stem tuber, after which they were abstained for the time being, anesthetized with chloroform and forfeited. The outcome showed that there was a huge increment (p<0.05) in mean body weight of the positive control and the treatment gatherings (200mg/kg to 600 mg/kg) when contrasted and the negative control which has a critical decline (p<0.05) in mean body weight. The outcome showed that there was a significant decline in blood glucose of creatures regulated with various dosages of fluid concentrate of Colocasia esculenta stem tuber and the positive benchmark group. Notwithstanding, there was a huge increment (P<0.05) in blood glucose of diabetic creatures in bad gathering when contrasted and the benchmark group.