Modern methods of acute myocardial infarction (AMI) treatment allow to avoid early postinfarction remodeling, but increase the number of patients with chronic heart failure (CHF) and preserved systolic heart function. The stiffness of the main arteries in patients with CHF and preserved left ventricular (LV) ejection fraction (EF) after AMI has been found to be increased. The severity of CHF depends on the increase in pulse wave velocity. The relationship between increased arterial stiffness and BNP and NT-pro BNP levels in patients with CHF with preserved LV EF 1 year after AMI was revealed.

In modern dentistry, the term C- factor, or Configuration Factor, has just recently gained popularity. Itsworth is determined by a direct restoration's initial polymerization stress assessment. It's also worth noting that, in today's dentistry, composite materials with excellent aesthetic, physical, and mechanical benefits are the most popular way of treating defects in the hard tissues of the tooth. The concern of shrinkage during the polymerization of the material, as previously mentioned, remains relevant. In cavities with high C-factor values, the impact of polymerization stress is especially noticeable. These difficulties, as well as their impact and solutions, will be discussed in this thesis.

The research has focused on the frequency, causes and consequences of thrombocytopathies acquired at all stages of pregnancy. The purpose of which was identification of the frequency and characteristics of thrombocytopathies at different stages of pregnancy. Clinical material for the study was obtained from 30 pregnant women aged 18-35 years who were treated from January 2021 to March 2022 in the department of pathology of pregnant women of the Tashkent Medical Clinic of the Ministry of Health of the Republic of Uzbekistan.

Late delayed post-radiation encephalopathy mainly occurs following whole brain irradiation and is very rarely associated with focused beam irradiation. The radiation lesions consist of areas of focal necrosis and of diffuse demyelization of the deep cerebral structures. Irradiating normal tissues leads to a chronic increases in reactive oxygen/reactive nitrogen oxide species. The clinical post-radiation symptoms are consistent with a progressive multifocal leukoencephalopathy. They include seizures, hemiparesis, cranial neuropathy, headaches, blindness, dementia, and ataxia. Neuroimaging is useful to distinct radiation-induced encephalopathy from tumour recurrence, but also to show the typical post-radiation features. For small, asymptomatic lesions, an observational wait strategy can be observed. Dexamethasone is the most used drug in symptomatic patients. Other types of treatment have also been investigated.

Various methods of surgical treatment of recurrent liver EC are described in domestic and foreign literature. The choice of surgical approach, the nature and volume of the operation, the method of treating the cyst, the need for drainage or elimination of the residual cavity are still subjects of discussion. In this regard, this chapter is devoted to our developments on key issues that affect the results of surgical treatment, complications and its nature in the immediate postoperative period, quality of life, rehabilitation and work capacity in the long term.

Vascular diseases of the brain due to their high prevalence and severe consequences for the health of the population represent a major medical and social problem. In the structure of cerebrovascular diseases significant weight have chronic forms of vascular lesions of the brain, which in the domestic literature is traditionally treated as a discirculatory encephalopathy. In Uzbekistan the number of sufferers with chronic forms of cerebrovascular diseases is increasing, therefore the urgency of solving this problem in Uzbekistan can be defined as an extreme one, requiring the concentration of efforts of specialists in different fields.

More than half of women worldwide suffer from anemia during pregnancy. It causes functional disorders of various organs and systems, lowers the quality of life and work capacity and increases the risk of complications during delivery. In the absence of timely and adequate therapy, iron deficiency may also occur in the fetus.

This article discusses the health of schoolchildren and adolescents and assesses their quality of life.

Analysis of the literature on the study of epidemiological features of maxillary malformations (cleft lip and palate) has shown their wide and widespread prevalence, having a heterogeneous nature depending on one region or another.  Research in this direction is undoubtedly relevant and necessary, since it will allow the timely detection and treatment of children with maxillary malformations, which will significantly improve the quality and life expectancy of these patients, leading to their full social adaptation.

This article presents the morphofunctional state of the thymus, its absolute weight was measured and its weight index relative to the body was calculated. Area of cortex and nucleus accumbens for analysis of intra-organ structures of the thymus, index of cortex in relation to the stratum corneum, the density of lymphocytes in the conditional area of the histological specimen.

A statistical summary of epidemiological studies conducted by the World Health Organization (WHO) over the past 10 years has noted a global increase in the incidence of allergic diseases [1,7]. According to an official statement from the World Allergy Organization (WAO), the number of total allergens has now tripled, particularly the incidence of allergic ophthalmopathologies has increased by 25% [2,4].

Immunopathogenetic basis of allergic eye diseases is the activation of histamine receptors (H) and degranulation of mast cells [5,9,12]. The main purpose of this article is to review and analyze the existing scientific literature on olopatadine hydrochloride (Olopan 0.1% eye drop ), which is a relatively new topical antiallergic drug in ophthalmological practice, as well as to evaluate the effectiveness of Olopan drug by means of clinical research.

According to the results of laboratory experimentations in rabbits, almost all conjunctival allergic symptoms (conjunctival hyperemia, tearing, swelling of the eyelids, redness and chemosis) caused by specific allergens (eg, histamine allergic mediator) were eliminated in a short time. [1,3,6,14]. In this type of animal research or animal experimentation, olopatadine hydrochloride solution has been shown to have both antihistamine and membrane cell stabilizer properties [8, 10,11].