Paraquat dichloride is a toxic bipyridine herbicide widely used for weed control in fruit orchards and forestry. Its fumes primarily affect the lungs due to preferential accumulation in lung alveolar cells. Aim: This study investigates paraquat toxicity in pregnant Wistar rats at varying doses over a three-week gestational period. Methods: A total of seventy-two Wistar rats were used, with 48 females entering the experimental phase after mating with males. The female rats were randomly divided into four groups: Group 1 (Normal female, n=12), Group 2 (1 mg/ml/kg bw of paraquat dichloride, n=12), Group 3 (2.5 mg/ml/kg bw, n=12), and Group 4 (5 mg/ml/kg bw, n=12). Tissues were examined weekly and prepared for histological analysis using a Primo Star ZEISS light microscope. Results: At the end of the third week, lung tissue sections exhibited varying degrees of injury, including mild inflammation, taller and slender respiratory epithelium indicating stress, bronchiolar dilation, and fibrotic changes in lung stroma. Notably, the lungs of the foetuses showed no significant histological differences compared to controls. Conclusion: Maternal exposure to paraquat during pregnancy results in dose-dependent lung inflammation and fibrosis. Recommendations for new policies to prevent perinatal maternal exposure to paraquat are warranted.

Fatty liver disease (FLD) is a growing global health concern, encompassing a spectrum of liver conditions ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which can lead to cirrhosis and liver failure. Early diagnosis and effective management of FLD are critical to preventing its progression and improving patient outcomes. This study proposes a comprehensive approach to assessing fatty liver disease by integrating clinical, biochemical, and radiological data. By combining patient history, biochemical markers, and advanced imaging techniques, this multifaceted diagnostic approach provides a more accurate and holistic understanding of the disease, enhancing early detection and personalized treatment strategies. Clinical data, such as risk factors and symptoms, serve as the initial screening tools, while biochemical markers offer insights into liver function and metabolic disturbances. Radiological imaging, including ultrasound, elastography, and MRI, plays a crucial role in assessing liver fat content, fibrosis, and overall liver health. This integrated methodology aims to refine diagnostic accuracy, enable timely intervention, and improve patient outcomes in individuals affected by fatty liver disease.