This article presents the origin, mechanism of development of fungal and parasitic infections, and morphological changes that occur in tissues under their influence. Diseases caused by fungi and parasites are characterized by a chronic course in the human body. These pathologies cause a significant decrease in the immune system and the development of structural and functional changes in internal organs. Pathological processes accompanied by deep tissue damage play a leading role in the pathogenesis of fungal infections. In this case, as a result of chronic inflammation in the epithelium, connective tissue and internal organs, granulomas are formed, foci of necrosis appear, and destructive changes alternate with fibrosis and dystrophy. Direct mechanical damage to tissues by pathogens during parasitic invasions causes hemodynamic disorders and pathological changes in the vascular walls. Also, as a result of the specific reaction of the organism, inflammatory infiltrates rich in eosinophils are formed in the area and deep dystrophic processes develop.  In parasitic infections, special attention is paid to morphological processes that develop as a result of mechanical damage, toxic-allergic effects and immunopathological reactions. The article systematically and clearly analyzes the macro- and microscopic changes that occur in organs as a result of these infections. At the same time, the role of pathoanatomical signs in differential diagnosis and their practical significance in making an accurate clinical diagnosis are substantiated.

Fungal infections, parasitic diseases, etiopathogenesis, pathoanatomical changes

Ivanov A.A. Medical Mycology. Moscow, 2020.

Robbins S.L., Cotran R.S. Pathologic Basis of Disease. Philadelphia: Elsevier, 2021.

Kumar V., Abbas A.K., Aster J.C. Basic Pathology. Philadelphia: Elsevier, 2022.

Mandell G.L., Bennett J.E., Dolin R. Principles and Practice of Infectious Diseases. New York: Elsevier, 2020.

Garcia L.S. Diagnostic Medical Parasitology. Washington DC: ASM Press, 2021.

Ismailov I.I. Pathomorphology of infectious diseases. Tashkent: Science and Technology, 2021.