This study investigates the potential additional effect of surgical removal of omental fat on metabolic markers and body mass index (BMI) in early stage gynecologic malignancies. Omental fat, an active endocrine organ, has been implicated in the pathogenesis of metabolic disturbances and cancer progression. Leveraging a cohort of patients with early stage gynecologic malignancies undergoing omentectomy, this research examines changes in metabolic markers, including glucose, insulin, lipid profiles, and BMI, following surgical intervention. The study employs preoperative and postoperative assessments, enabling a comparative analysis of metabolic outcomes. The findings offer insights into the complex interplay between omental fat, metabolic alterations, and cancer, potentially guiding therapeutic approaches aimed at optimizing metabolic health in gynecologic malignancy patients.

surgical removal, metabolic markers, body mass index

World health organization (WHO) 2011

Bays H, Abate N, Chandalia M. Adiposopathy: sick fat causes high blood sugar, high blood pressure, and dyslipidemia. Future Cardiol 2005;1:39–59

Bays H, Ballantyne C. Adiposopathy: why do adiposity and obesity cause metabolic disease? Future Lipidol 2006;1:389–420

Bays HE. “Sick fat,” metabolic disease, and atherosclerosis. Am J Med 2009;122:26–37

Bays HE, Gonzalez-Campoy JM, Henry RR, Bergman DA, Kitabchi AE, Schorr AB, et al. Is adiposopathy (sick fat) an endocrine disease? Int J Clin Pract 2008;62:1474–83

Bays HE, Gonzalez-Campoy JM, Bray GA, Kitabchi AE, Bergman DA, Schorr AB, et al. Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev Cardiovasc Ther 2008;6:343–68

Klein S, Fontana L, Young VL, Coggan AR, Kilo C, Patterson BW, et al. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med 2004;350:2549–57.

Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, et al. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 1999;48:94–8.

Pitombo C, Araújo EP, De Souza CT, Pareja JC, Geloneze B, Velloso LA. Amelioration of diet- induced diabetes mellitus by removal of visceral fat. J Endocrinol 2006;191:699–706

Lottati M, Kolka CM, Stefanovski D, Kirkman EL, Bergman RN.Greater omentectomy improves insulin sensitivity in nonobese dogs.Obes Silver Spring 2009;17:674–80.