Articles | Open Access | Vol. 3 No. 06 (2023): Volume 03 Issue 06 | DOI: https://doi.org/10.37547/medical-fmspj-03-06-01

DESIGN, SYNTHESIS, AND ANTIBACTERIAL EVALUATION OF NOVEL HETEROCYCLIC COMPOUNDS: A PROMISING APPROACH FOR COMBATTING BACTERIAL INFECTIONS

Kapil Kumar Saxena , Department Of Chemistry Atarra P.G.Collage Atarra Banda U.P., India

Abstract

The increasing prevalence of antibiotic-resistant bacterial infections has necessitated the development of new therapeutic approaches. In this study, we focused on the design, synthesis, and antibacterial evaluation of novel heterocyclic compounds as potential candidates for combatting bacterial infections. A diverse set of heterocyclic scaffolds were synthesized using efficient synthetic methodologies. The antibacterial activity of the compounds was assessed against a panel of clinically relevant bacterial strains, highlighting their potential as promising antimicrobial agents. This research contributes to the ongoing efforts in discovering novel strategies for addressing antibiotic resistance and combating bacterial infections

Keywords

Antibacterial evaluation, antibiotic resistance,, heterocyclic compounds

References

Surpuran, C.T.; Scozzafava, A.; Jurca, B.C.; Ilies, M.A. Carbonic anhydrase inhibitors. Part 49. Synthesis of substituted ureido and thioureido derivatives of aromatic / heterocyclic sulfonamides with increased affinities for isozyme I. Eur. J. Med. Chem. 1998, 33,83–93.

Di Fiore, A.; Monti, S.M.; Innocenti, A.; Winuma, J.-Y.; De Simone, G.; Supuran, C.T. Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron- containing aromatic sulfamide with mammalian isoforms I–XV. Bioorg. Med. Chem. Lett. 2010, 20, 3601– 3605.

Smaine, F.-Z.; Pacchiano, F.; Rami, M.; Barragan-Montero, V.; Vullo, D.; Scozzafava, A.; Winuma, J.-Y.; Supuran, C.T. Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5- sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VBover the cytosolic and membrane- associated carbonic anhydrases I, II and IV. Bioorg. Med. Chem. Lett. 2008, 18,6332–6335.

Gadad, A.K.; Mahajanshetti, C.S.; Nimbalkar, S.; Raichurkar, A. Synthesis and antibacterial activity of some 5-guanylhydrazone/thiocyanato-6-arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide derivatives. Eur. J. Med. Chem. 2000, 35,853–857.

Sondhi, S.M.; Johar, M.; Singhal, N.; Dastidar, S.G.; Shukla, R.; Raghubir, R. Synthesis and anticancer, anti-inflammatory and analgesic activity evaluation of some drugs and acridine derivatives. Monatsh. Chem. 2000, 131,511–520.

Dow, R.L.; Paight, E.S.; Schneider, S.R.; Hadcock, J.R.; Hargrove, D.M.; Martin, K.A.; Maurer, T.S.;Nardone, N.A.; Tess, D.A.; DaSilva-Jardinea, P. Potent and selective, sulfamide-based human β3- adrenergic receptor agonists. Bioorg. Med. Chem. Lett. 2004, 14,3235–3240.

Patel, S.D.; Habeski, W.M.; Cheng, A.C.; de la Cruz, E.; Loh, C.; Kablaoui, N.M. Quinazolin-4- piperidin- 4-methyl sulfamide PC-1 inhibitors: Alleviating hERG interactions through structure based design. Bioorg. Med. Chem. Lett. 2009, 19,3339–3343.

Ezabadi, I.R.; Canoutsis, C.; Zoumpoulakis, P.; Geronikaki, A.; Sokovic, M.; Glamocilija, J.; Ciric, A. Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies. Bioorg. Med. Chem. 2008, 16, 1150–1161.

Chen, Z.; Xu, W.; Liu, K.; Yang, S.; Fan, H.; Bhadury, P.S.; Hu, D.-Y.; Zhang, Y. Synthesis and antiviral activity of 5-(4-chlorophenyl)-1,3,4-thiadiazole sulfonamides. Molecules 2010, 15,9046–9056.

Azab, M.E.; Ibraheem, M.E.A.; Madkour, H.M.F. The utility of 2-(5,6,7,8-tetrahydro- benzo[b]thieno[2,3- d]pyrimidin-4-yloxy)acethydrazide in heterocyclic synthesis. Phosphorus Sulfur Silicon Relat. Elem. 2006, 181,1299–1313.

Salem, M.A.I.; Soliman, E.A.; Smith, M.B.; Mahmoud, M.R.; Azab, M.E. Utility of 1-(2,4- Dimethoxyphenyl)-3-arylprop-2-ene-1-ones as ring transformer in preparing heterocyclic compounds and their potential biological activities. Phosphorus Sulfur Silicon Relat. Elem. 2004, 179, 61–76.

Azab, M.E. Utility of enaminonitrile moiety in the synthesis of some biologically active thienopyrimidine derivatives. Phosphorus Sulfur Silicon Relat. Elem. 2008, 183,1766–1782.

Madkour, H.M.F.; Azab, M.E.; Ibraheem, M.A.E. 5,6,7,8-Tetrahydrobenzo[b]thieno-[2,3-d]pyrimidin- 4(3H)-one as a synthon of heterocyclic systems. Bullgarian Chem. Commun. 2009, 41,12–18.

Mahmoud, M.R.; El-Bassiouny, F.A.; Azab, M.E.; El-Kady, M.Y.; Rashed, H.M. Heteroannulation of chromene derivatives. Synthesis of chromeno[4,3-e]indazolne, chromeno [4,3-f]quinazoline and pyrano[3,2-c]chromene derivatives. J. Chem. Res. 2009, 1,41–45.

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Kapil Kumar Saxena. (2023). DESIGN, SYNTHESIS, AND ANTIBACTERIAL EVALUATION OF NOVEL HETEROCYCLIC COMPOUNDS: A PROMISING APPROACH FOR COMBATTING BACTERIAL INFECTIONS. Frontline Medical Sciences and Pharmaceutical Journal, 3(06), 1–6. https://doi.org/10.37547/medical-fmspj-03-06-01