The article presents the findings of the research on the antagonistic properties of lactobacillus strains against conditionally pathogenic clinical isolates that cause intestinal inflammation. Conditionally pathogenic clinical isolates of colon (large intestine) and rectum (straight intestine) were isolated and identified to the described species level. From a variety of dairy products, 28 milk-fermenting lactobacilli were isolated, screened, and their probiotic probiotic properties were studied. From 28 isolates of isolated milk-fermenting bacteria, 7 strains were selected. The selected strains showed high antimicrobial activity against clinical and typical conditional pathogenic isolates causing intestinal inflammatory diseases (ulcerative colitis). For this reason, these strains can be recommended as a means of treatment and prevention of intestinal infections.

Lactobacillus strains, IBD, intestinal infections

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Методические указания «МУК 4.2.2602-10. Методы контроля. Биологические и микробиологические факторы. Система предрегистрационного доклинического изучения безопасности препаратов. Отбор, проверка и хранение производственных штаммов, используемых при производствепробиотиков»от 21.04.2010.

Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ под общей редакцией члена-корреспондента РАМН, профессора Р.У. Хабриева. - Издание 2-е, переработанное и дополненное – Москва, 2005.