Pregnancy associated with a variety of physiological consequences on several organs and bodily systems, including the renal system. These effects can be investigated us-ing biochemical measures that are useful in determining renal function. In a recent re-search, the blood of 82 healthy pregnant women was tested for three parameters: urea, uric acid, and crеаtinine. The women were separated into three subgroups based ac-cording to gestational age (first, second, and third trimester). As properly as, 33 curi-ously healthful non pregnant girls as a control group, in order to look at the physiolog-ical results of pregnancy on some renal feature checks as well as, identify the impact of gestational age on these laboratory parameters. It is determined that for the dura-tion of first and second trimesters of pregnancy, the suggest values of serum urea, uric acid, and creatinine was appreciably decrease in the pregnant crew than in controls. During the third trimester, the levels of serum urea, uric acid, and crеаtinine decreased non-significantly when compare to controls. The differences in values of serum uric acid, urea, and crеаtinine levels within different trimesters show a significant changes between the third trimester and the first and second  trimesters, with third  trimester being greater than the first and second  trimesters, while the first and second  tri-mesters appear no significant difference.

Creatinine, Urea

Pregnancy; Condition Information. http://www.nichd.nih.gov/. December 19, 2013. External link in |website= (help) Retrieved 14 March, 2015.

Dilipkumar M Kava, Hasit D Lad., Comparative study of assessment of renal func-tion in pregnant women with non-pregnant women. Med Pulse International Journal of Biochemistry. September 2019;11(3):90-95.

Abman, Steven H., Fetal and neonatal physiology (4th ed.). Philadelphia: Elsevier/ Saunders, 2011; 46–47.

Yanamandra N, Chandraharan E (n.d)., Anatomical and physiological changes in pregnancy and their implications in clinical practice. In (pp. 1-8) Doi.10.1017/CBO9780511842153.002

Priya Soma-Pillay, Catherine Nelson-Piercy, Heli Tolppanen, Alexandre Mebazaa., Physiological changes in pregnancy. Cardiovascular Journal of Africa. Volume 27, No 2, March/April 2016:89-94 AFRICA.

David Ind, RN, BN, BSc, MEd., Pregnancy and Renal Function; Coordinator Nephrology Nursing Program, The Queen Elizabeth Hospital Renal Society of Aus-tralasia Journal // July 2007 Vol 3 No: 2: 47-49.

Okoro RN, Farate VT., The use of nephrotoxic drugs in patients with chronic kidney disease. Int J Clin Pharm., 2019 Jun;41(3):767-775. [PubMed]

Nwose EU, Obianke J, Richards RS, Bwitit PT, Igumbor EO., Prevalence and cor-relations of hepato renal functions in diabetes and cardiovascular disease among strati-fied adults. Acta Biomed., 2019 Jan 22;90(1):97-103. [PMC free article] [PubMed]

Cheung KL, Lafayette RA., Renal physiology of pregnancy. Adv Chronic Kidney Dis., 2013; 20(3): 209–214.

Livingston JR, Payne B, Brown M, et al., Uric Acid as a predictor of adverse ma-ternal and perinatal outcomes in women hospitalized with preeclampsia. J Obstet Gy-naecolCan., 2014; 36: 870–7..